Associations of air pollution with obesity and body fat percentage, and modification by polygenic risk score for BMI in the UK Biobank.

ABSTRACT: Air pollution has consistently been associated with cardiometabolic outcomes, although associations with obesity have only been recently reported. Studies of air pollution and adiposity have mostly relied on body mass index (BMI) rather than body fat percentage (BF%), and most have not accounted for noise as a possible confounder. Additionally, it is unknown whether genetic predisposition for obesity increases susceptibility to the obesogenic effects of air pollution. To help fill these gaps, we used the UK Biobank, a large, prospective cohort study in the United Kingdom, to explore the relationship between air pollution and adiposity, and modification by a polygenic risk score for BMI. We used 2010 annual averages of air pollution estimates from land use regression (NO₂, NO

SUBMITTER: Furlong MA 

PROVIDER: S-EPMC7199644 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature