Heritability of telomere length across three generations of Korean families.

ABSTRACT:

Background

Leukocyte telomere length (LTL), an indicator of aging, is influenced by both genetic and environmental factors; however, its heritability is unknown. We determined heritability and inheritance patterns of telomere length across three generations of families.

Methods

We analyzed 287 individuals from three generations of 41 Korean families, including newborns, parents, and grandparents. LTL (the ratio of telomere repeat copy number to single gene copy number) was measured by quantitative real-time PCR. We estimated heritability using the SOLAR software maximum-likelihood variance component methods and a pedigree dataset. With adjustment for age and length of marriage, Pearson's partial correlation was performed for spousal pairs.

Results

Heritability of LTL

SUBMITTER: Kim JH 

PROVIDER: S-EPMC7199797 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature