Ontology highlight
ABSTRACT:
SUBMITTER: Pfisterer K
PROVIDER: S-EPMC7199847 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Pfisterer Karin K Levitt James J Lawson Campbell D CD Marsh Richard J RJ Heddleston John M JM Wait Eric E Ameer-Beg Simon Morris SM Cox Susan S Parsons Maddy M
The Journal of cell biology 20200501 5
Filopodia are peripheral F-actin-rich structures that enable cell sensing of the microenvironment. Fascin is an F-actin-bundling protein that plays a key role in stabilizing filopodia to support efficient adhesion and migration. Fascin is also highly up-regulated in human cancers, where it increases invasive cell behavior and correlates with poor patient prognosis. Previous studies have shown that fascin phosphorylation can regulate F-actin bundling, and that this modification can contribute to ...[more]