Effect of short-term prednisone on beta-cell function in subjects with type 2 diabetes mellitus and healthy subjects.

ABSTRACT:

Objective

For those with type 2 diabetes mellitus (T2DM), impact of short-term high-dose glucocorticoid exposure on beta-cell function is unknown. This study aims to compare the impact on beta-cell function and insulin resistance of prednisone 40 mg between adults with newly diagnosed T2DM and healthy adults.

Methods

Five adults with T2DM and five healthy adults, all between 18-50 years, were enrolled. T2DM diagnosis was less than one year prior, HbA1c<75 mmol/mol (9.0%), with metformin treatment only. Pre- and post-therapy testing included 75-g oral glucose tolerance, plasma glucose, C-peptide, and insulin. Intervention therapy was prednisone 40mg daily for 3 days.

Results

Upon therapy completion, HOMA-IR did not increase or differ between groups. Percentile differen

SUBMITTER: Shah M 

PROVIDER: S-EPMC7199958 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature