Research of the mechanism on miRNA193 in exosomes promotes cisplatin resistance in esophageal cancer cells.

ABSTRACT:

Purpose

Chemotherapy resistance of esophageal cancer is a key factor affecting the postoperative treatment of esophageal cancer. Among the media that transmit signals between cells, the exosomes secreted by tumor cells mediate information transmission between tumor cells, which can make sensitive cells obtain resistance. Although some cellular exosomes play an important role in tumor's acquired drug resistance, the related action mechanism is still not explored specifically.

Methods

To elucidate this process, we constructed a cisplatin-resistant esophageal cancer cell line, and proved that exosomes conferring cellular resistance in esophageal cancer can promote cisplatin resistance in sensitive cells. Through high-throughput sequencing analysis of the exosome and of cells af

SUBMITTER: Shi S 

PROVIDER: S-EPMC7199973 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature