Treatment and re-treatment results of HCV patients in the DAA era.

ABSTRACT: BACKGROUND:Re-treatment in patients with a chronic hepatitis C virus (HCV) infection and a previous failure to direct-acting antiviral (DAA) treatment remains a challenge. Therefore, we investigated the success rate of treatment and re-treatment regimens used at our center from October 2011 to March 2018. METHODS:A retrospective analysis of DAA-based HCV therapies of 1096 patients was conducted. Factors associated with a virological relapse were identified by univariable and multivariable logistic regression, treatment success of the re-treatment regimens was evaluated by an analysis of sustained virological response (SVR) rates in patients with a documented follow-up 12 weeks after the end of treatment. RESULTS:Of 1096 patients treated with DAA-based regimens, 91 patients (8%) were lost t

SUBMITTER: Piecha F 

PROVIDER: S-EPMC7200014 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature