Integrative and quantitative view of the CtrA regulatory network in a stalked budding bacterium.

ABSTRACT: The Alphaproteobacteria show a remarkable diversity of cell cycle-dependent developmental patterns, which are governed by the conserved CtrA pathway. Its central component CtrA is a DNA-binding response regulator that is controlled by a complex two-component signaling network, mediating distinct transcriptional programs in the two offspring. The CtrA pathway has been studied intensively and was shown to consist of an upstream part that reads out the developmental state of the cell and a downstream part that integrates the upstream signals and mediates CtrA phosphorylation. However, the role of this circuitry in bacterial diversification remains incompletely understood. We have therefore investigated CtrA regulation in the morphologically complex stalked budding alphaproteobacterium Hyphomo

SUBMITTER: Leicht O 

PROVIDER: S-EPMC7200025 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature