Live birth after in vitro maturation versus standard in vitro fertilisation for women with polycystic ovary syndrome: protocol for a non-inferiority randomised clinical trial.

ABSTRACT:

Introduction

Polycystic ovary syndrome (PCOS) is the first common cause of anovulatory infertility. Currently, in vitro fertilisation (IVF) is recommended when conventional attempts have failed. In vitro maturation (IVM) of human oocytes is an emerging treatment option in infertile women with PCOS. It is a patient-friendly intervention, avoiding the risk of ovarian hyperstimulation syndrome, which is a serious complication of controlled ovarian stimulation in the standard IVF procedure. We plan a randomised controlled trial (RCT) to evaluate whether IVM is non-inferior to the standard IVF for live birth in women with PCOS.

Methods and analysis

This is a single-centre, open-label, non-inferiority RCT performed in a large reproductive medicine centre in China. Infertile women

SUBMITTER: Zheng X 

PROVIDER: S-EPMC7200037 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature