Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings.

ABSTRACT: BACKGROUND:Human respiratory system infected with influenza A virus (IAV) elicited a robust pro-inflammatory response that resulted in severe illness and even death. Currently, limited immunomodulator is available to counteract IAV-associated pneumonia in the clinic. Sinensetin, a polymethoxylated flavone with five methoxy groups, has been found to possess anti-agiogenesis, anti-inflammatory and anti-diabetic activities. However, the effects of sinensetin on IAV-triggered pro-inflammatory response remain unclear. In the present study, the anti-inflammatory effects and corresponding possible mechanism of sinensetin in IAV-infected A549 cells were subjected to investigations. METHODS:The cytotoxic effects of sinensetin towards A549 cells was detected by MTT and LDH assays. The antiviral acti

SUBMITTER: Li J 

PROVIDER: S-EPMC7200050 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature