Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight.

ABSTRACT:

Aim

To determine if genetic variation associated with decreased dopamine neurotransmission predicts a decrease in motor development in a convenience cohort study of infants born extremely-low-birthweight (ELBW).

Method

Four hundred and ninety-eight infants born ELBW had genome-wide genotyping and a neurodevelopmental evaluation at 18 to 22 months of age, corrected for preterm birth. A polygenic risk score (PRS) was created to combine into one predictor variable the hypothesized influences on motor development of alleles at seven independent single nucleotide polymorphisms previously associated with relative decreases in both dopamine neurotransmission and motor learning, by summing the number of alleles present in each infant (range=0-14). The motor development outcome was t

SUBMITTER: Worley G 

PROVIDER: S-EPMC7200269 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature