Association of visceral adiposity and systemic inflammation with sleep disordered breathing in normal weight, never obese adolescents.

ABSTRACT:

Objective/background

While obesity is a known risk factor for sleep disordered breathing (SDB), a large proportion of children with SDB are not overweight as per body mass index percentile (BMI%) criteria. This study aimed to examine whether premorbid or concurrent adiposity phenotypes and inflammation are associated with SDB in normal weight youth.

Patients/methods

A total of 242 persistently non-overweight (BMI%<85) subjects from the Penn State Child Cohort (PSCC, N = 421, 5-12 y at baseline and 12-23 y at follow-up), were studied. The apnea/hypopnea index (AHI) was ascertained via polysomnography (PSG) at both time points. At follow-up, a dual-energy X-ray absorptiometry (DXA) scan assessed android and gynoid distribution and subcutaneous (SAT) and visceral (VAT) adiposit

SUBMITTER: Danisi JM 

PROVIDER: S-EPMC7200279 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature