Circulating omega-7 fatty acids are differentially related to metabolic dysfunction and incident type II diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Aim

Determine whether plasma omega-7 vaccenic acid and palmitoleic acid levels are related to homeostasis model of insulin resistance scores and incident type II diabetes, and whether race/ethnicity modifies these associations.

Methods

Plasma phospholipid fatty acids were measured by gas chromatography with flame-ionization detection in Multi-Ethnic Study of Atherosclerosis participants. Linear regression determined associations of vaccenic acid and palmitoleic acid with log-transformed homeostasis model of insulin resistance scores (n=5689), and Cox regression determined associations with incident type II diabetes (n=5413, 660 cases). Race-interactions were tested.

Results

Adjusting for typical risk factors, higher levels of plasma vaccenic acid were found to be inve

SUBMITTER: Weir NL 

PROVIDER: S-EPMC7200281 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature