Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle.

ABSTRACT: Coronavirus are the causative agents in many globally concerning respiratory disease outbreaks such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease-2019 (COVID-19). It is therefore important that we improve our understanding of how the molecular components of the virus facilitate the viral life cycle. These details will allow for the design of effective interventions. Krichel and coauthors in their article in the Biochemical Journal provide molecular details of how the viral polyprotein (nsp7-10) produced from the positive single stranded RNA genome, is cleaved to form proteins that are part of the replication/transcription complex. The authors highlight the impact the polyprotein conformation has on the cleavage efficiency of th

SUBMITTER: Gildenhuys S 

PROVIDER: S-EPMC7200640 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature