Comparative genomic analysis of inbred rat strains reveals the existence of ancestral polymorphisms.

ABSTRACT: In an alignment of closely related genomic sequences, the existence of discordant mutation sites, which do not reflect the phylogenetic relationship of the genomes, is often observed. Although these discordant mutation sites are thought to have emerged by ancestral polymorphism or gene flow, their frequency and distribution in the genome have not yet been analyzed in detail. Using the genome sequences of all protein coding genes of 25 inbred rat strains, we analyzed the frequency and genome-wide distribution of the discordant mutation sites. From the comparison of different substrains, it was found that these loci are not substrain specific, but are common among different groups of substrains, suggesting that the discordant sites might have mainly emerged through ancestral polymorphism. It

SUBMITTER: Kim H 

PROVIDER: S-EPMC7200647 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature