Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice.

ABSTRACT: Cell-based therapies are promising treatments for various kidney diseases. However, the major hurdle in initiating therapeutic responses is the inefficiency of injection routes to deliver cells to the kidney parenchyma. Systemic injection, such as intravenous injection only delivers a small proportion of cells to the kidney. Whereas direct delivery, such as renal artery injection requires surgical procedures. A minimally invasive renal artery injection was therefore developed to enhance cell delivery to kidney. In this study, luciferase expressing human adipocyte derived stem cells (ADSC) were labelled with gold nanorods (GNR) and injected into the renal artery using ultrasound guidance. The ADSCs were tracked using bioluminescence and photoacoustic imaging serially over 7 days. Imaging co

SUBMITTER: Zaw Thin M 

PROVIDER: S-EPMC7200714 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature