Individual and cohort-specific gut microbiota patterns associated with tissue-specific insulin sensitivity in overweight and obese males.

ABSTRACT: A growing body of evidence suggests that the human gut microbiota plays a role in the development of obesity and related metabolic diseases. However, there is little consensus between studies, which could be due to biological as well as technical variation. In addition, little human data are available to investigate whether tissue-specific insulin sensitivity is related to specific microbial patterns. We examined this relation in two independent cohorts of overweight and obese pre-diabetic men, using phylogenetic microarray data and hepatic, peripheral and adipose tissue insulin sensitivity that were determined by a two-step hyperinsulinemic-euglycemic clamp with [6,6-²H₂]-glucose tracer infusion. Despite a prominent subject-specific microbiota, we found significant a

SUBMITTER: Hermes GDA 

PROVIDER: S-EPMC7200728 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature