MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth.

ABSTRACT: Mitochondrial calcium uniporter (MCU) has an important role in regulating mitochondrial calcium (Ca²⁺) homeostasis. Dysregulation of mitochondrial Ca²⁺ homeostasis has been implicated in various cancers. However, it remains unclear whether MCU regulates mitochondrial Ca²⁺ uptake to promote cell growth in colorectal cancer (CRC). Therefore, in the present study the expression of MCU in CRC tissues and its clinical significance were examined. Following which, the biological function of MCU-mediated mitochondrial Ca²⁺ uptake in CRC cell growth and the underlying mechanisms were systematically evaluated using in in vitro and in vivo assays, which included western blotting, cell viability and apoptosis assays, as well as xenograft nude mice models. Ou

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7200750 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature