Ontology highlight
ABSTRACT:
SUBMITTER: Slonchak A
PROVIDER: S-EPMC7200751 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Slonchak Andrii A Hugo Leon E LE Freney Morgan E ME Hall-Mendelin Sonja S Amarilla Alberto A AA Torres Francisco J FJ Setoh Yin Xiang YX Peng Nias Y G NYG Sng Julian D J JDJ Hall Roy A RA van den Hurk Andrew F AF Devine Gregor J GJ Khromykh Alexander A AA
Nature communications 20200505 1
Flaviviruses, including Zika virus (ZIKV), utilise host mRNA degradation machinery to produce subgenomic flaviviral RNA (sfRNA). In mammalian hosts, this noncoding RNA facilitates replication and pathogenesis of flaviviruses by inhibiting IFN-signalling, whereas the function of sfRNA in mosquitoes remains largely elusive. Herein, we conduct a series of in vitro and in vivo experiments to define the role of ZIKV sfRNA in infected Aedes aegypti employing viruses deficient in production of sfRNA. W ...[more]