Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation.

ABSTRACT: Restoration of the communication between brain circuitry is a crucial step in the recovery of brain damage induced by traumatic injuries or neurological insults. In this work we present a study of real-time unidirectional communication between a spiking neuronal network (SNN) implemented on digital platform and an in-vitro biological neuronal network (BNN), generating similar spontaneous patterns of activity both spatial and temporal. The communication between the networks was established using patterned optogenetic stimulation via a modified digital light projector (DLP) receiving real-time input dictated by the spiking neurons' state. Each stimulation consisted of a binary image composed of 8 × 8 squares, representing the state of 64 excitatory neurons. The spontaneous and evoked activit

SUBMITTER: Mosbacher Y 

PROVIDER: S-EPMC7200763 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature