MCL-1^Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions.

ABSTRACT: Mitochondria play a crucial role in neuronal survival through efficient energy metabolism. In pathological conditions, mitochondrial stress leads to neuronal death, which is regulated by the anti-apoptotic BCL-2 family of proteins. MCL-1 is an anti-apoptotic BCL-2 protein localized to mitochondria either in the outer membrane (OM) or inner membrane (Matrix), which have distinct roles in inhibiting apoptosis and promoting bioenergetics, respectively. While the anti-apoptotic role for Mcl1 is well characterized, the protective function of MCL-1 ^Matrix remains poorly understood. Here, we show MCL-1^OM and MCL-1^Matrix prevent neuronal death through distinct mechanisms. We report that MCL-1^Matrix functions to preserve mitochondrial energy transduction

SUBMITTER: Anilkumar U 

PROVIDER: S-EPMC7200794 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature