Babesia microti Confers Macrophage-Based Cross-Protective Immunity Against Murine Malaria.

ABSTRACT: Malaria and babesiosis, the two primary intraerythrocytic protozoan diseases of humans, have been reported in multiple cases of co-infection in endemic regions. As the geographic range and incidence of arthropod-borne infectious diseases is being affected by climate change, co-infection cases with Plasmodium and Babesia are likely to increase. The two parasites have been used in experimental settings, where prior infection with Babesia microti has been shown to protect against fatal malarial infections in mice and primates. However, the immunological mechanisms behind such phenomena of cross-protection remain unknown. Here, we investigated the effect of a primary B. microti infection on the outcome of a lethal P. chabaudi challenge infection using a murin

SUBMITTER: Efstratiou A 

PROVIDER: S-EPMC7200999 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature