Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity.

ABSTRACT:

Introduction

We investigated metabolites in plasma to capture systemic biochemical changes associated with Alzheimer's disease (AD).

Methods

Metabolites in plasma were measured in 59 AD cases and 60 healthy participants of African American (AA), Caribbean Hispanic (CH), and non-Hispanic white (NHW) ancestry using untargeted liquid-chromatography-based ultra-high-resolution mass spectrometry. Metabolite differences between AD and healthy, ethnic groups and apolipoprotein E gene (APOE) ε4 status were analyzed. Untargeted network analysis identified pathways enriched in AD-associated metabolites.

Results

A total of 5929 annotated metabolites were measured. Partial least squares discriminant analysis (PLS-DA) inferred that AD clustered separately from healthy contr

SUBMITTER: Vardarajan B 

PROVIDER: S-EPMC7201178 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature