Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.

ABSTRACT:

Background

Defining regulatory mechanisms through which noncoding risk variants influence the cell-mediated pathogenesis of immune-mediated disease (IMD) has emerged as a priority in the post-genome-wide association study era.

Objectives

With a focus on rheumatoid arthritis, we sought new insight into genetic mechanisms of adaptive immune dysregulation to help prioritize molecular pathways for targeting in this and related immune pathologies.

Methods

Whole-genome methylation and transcriptional data from isolated CD4⁺ T cells and B cells of more than 100 genotyped and phenotyped patients with inflammatory arthritis, all of whom were naive to immunomodulatory treatments, were obtained. Analysis integrated these comprehensive data with genome-wide association

SUBMITTER: Clark AD 

PROVIDER: S-EPMC7201180 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature