Natural Clostridioides difficile Toxin Immunization in Colonized Infants.

ABSTRACT:

Background

Clostridioides (Clostridium) difficile colonization is common among infants. Serological sequelae of infant C. difficile colonization are poorly understood.

Methods

In this prospective cohort study of healthy infants, stools serially collected between ages 1-2 and 9-12 months were tested for non-toxigenic and toxigenic C. difficile (TCD). Cultured isolates underwent whole-genome sequencing. Serum collected at 9-12 months underwent measurement of IgA, IgG, and IgM against TCD toxins A and B and neutralizing antibody (NAb) titers against toxin B. For comparison, antitoxin IgG and NAb were measured in cord blood from 50 mothers unrelated to study infants.

Results

Among 32 infants, 16 (50%) were colonized with TCD; 12 were first colonized >1 month before serolo

SUBMITTER: Kociolek LK 

PROVIDER: S-EPMC7201415 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature