Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions.

ABSTRACT:

Rationale

Macrophages are essential regulators of atherosclerosis. They secrete cytokines, process lipoproteins and cholesterol, and take up apoptotic cells. Multiple subsets of plaque macrophages exist and their differential roles are emerging.

Objective

Here, we explore macrophage heterogeneity in atherosclerosis plaques using transgenic fluorescent mice in which subsets of macrophages are labeled by GFP (green fluorescent protein), YFP (yellow fluorescent protein), neither, or both. The objective was to define migration patterns of the visible subsets and relate them to their phenotypes and transcriptomes.

Methods and results

Apoe^-/-Cx3cr1^GFPCd11c^YFP mice have 4 groups of macrophages in their aorta

SUBMITTER: McArdle S 

PROVIDER: S-EPMC7201888 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature