Ontology highlight
ABSTRACT:
SUBMITTER: Zhan X
PROVIDER: S-EPMC7201922 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200501 5
Type I interferons (IFNs) are known to mediate antineoplastic effects during tumor progression. Type I IFNs can be produced by multiple cell types in the tumor microenvironment; however, the molecular mechanisms by which tumor cells evade the inhibition of immune microenvironment remain unknown. Here we demonstrate that glioma stem-like cells (GSCs) evade type I IFN suppression through downregulation of STAT1 to initiate tumor growth under inhospitable conditions. The downregulation of STAT1 is ...[more]