TRPM7 activation potentiates SOCE in enamel cells but requires ORAI.

ABSTRACT: Calcium (Ca²⁺) release-activated Ca²⁺ (CRAC) channels mediated by STIM1/2 and ORAI (ORAI1-3) proteins form the dominant store-operated Ca²⁺ entry (SOCE) pathway in a wide variety of cells. Among these, the enamel-forming cells known as ameloblasts rely on CRAC channel function to enable Ca²⁺ influx, which is important for enamel mineralization. This key role of the CRAC channel is supported by human mutations and animal models lacking STIM1 and ORAI1, which results in enamel defects and hypomineralization. A number of recent reports have highlighted the role of the chanzyme TRPM7 (transient receptor potential melastanin 7), a transmembrane protein containing an ion channel permeable to divalent cations (Mg²⁺, Ca²⁺), as a mod

SUBMITTER: Souza Bomfim GH 

PROVIDER: S-EPMC7202080 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature