Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

ABSTRACT: Genomic studies in African populations provide unique opportunities to understand disease etiology, human diversity, and population history. In the largest study of its kind, comprising genome-wide data from 6,400 individuals and whole-genome sequences from 1,978 individuals from rural Uganda, we find evidence of geographically correlated fine-scale population substructure. Historically, the ancestry of modern Ugandans was best represented by a mixture of ancient East African pastoralists. We demonstrate the value of the largest sequence panel from Africa to date as an imputation resource. Examining 34 cardiometabolic traits, we show systematic differences in trait heritability between European and African populations, probably reflecting the differential impact of genes and environment. I

SUBMITTER: Gurdasani D 

PROVIDER: S-EPMC7202134 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature