Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017).

ABSTRACT:

Background and aims

Guatemala has the highest incidence of hepatocellular carcinoma (HCC) in the Western hemisphere. The major risk factors in Guatemala are not well characterized, but the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) appears to be low, while the prevalence of aflatoxin (AFB₁) exposure appears to be high. To examine whether AFB₁ may contribute to the elevated incidence of HCC in Guatemala, this study examined the frequency of the AFB₁-signature mutation in the TP53 gene (R249S) as well as other somatic mutations. In addition, we assessed whether the frequency of the TP53 mutation differed by sex.

Methods

Formalin-fixed, paraffin-embedded (FFPE) HCC tissues were obtained from three hospitals i

SUBMITTER: Alvarez CS 

PROVIDER: S-EPMC7202218 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature