Treatment of Helicobacter pylori Is Not Associated With Future Clostridium difficile Infection.

ABSTRACT:

Introduction

Helicobacter pylori (HP) infection is associated with many gastrointestinal disorders, including gastric cancer, and consensus guidelines recommend eradication after detection. There is a theoretical, yet uninvestigated, concern that HP treatment could increase the risk of Clostridium difficile infection (CDI). Using the data from a large cohort of patients with HP, we investigated whether HP eradication is associated with CDI.

Methods

A retrospective cohort study within the Veterans Health Administration on 38,535 patients (median age 61.8 years; 91.8% men) with detected HP between January 1, 1994, and December 31, 2018 was conducted. Primary outcome was a positive laboratory test for CDI within 3 months of HP detection. Multivariable logistic regression evalua

SUBMITTER: Kumar S 

PROVIDER: S-EPMC7202442 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature