A novel immune-related genes prognosis biomarker for melanoma: associated with tumor microenvironment.

ABSTRACT:

Background

Melanoma is a cancer of the skin with potential to spread to other organs and is responsible for most deaths due to skin cancer. It is imperative to identify immune biomarkers for early melanoma diagnosis and treatment.

Results

63 immune-related genes of the total 1039 unique IRGs retrieved were associated with overall survival of melanoma. A multi-IRGs classifier constructed using eight IRGs showed a powerful predictive ability. The classifier had better predictive power compared with the current clinical data. GSEA analysis showed multiple signaling differences between high and low risk score group. Furthermore, biomarker was associated with multiple immune cells and immune infiltration in tumor microenvironment.

Conclusions

The immune-related genes progn

SUBMITTER: Huang R 

PROVIDER: S-EPMC7202520 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature