Detection of IgM and IgG antibodies in patients with coronavirus disease 2019.

ABSTRACT:

Objectives

This study aimed to determine the IgM and IgG responses against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with varying illness severities.

Methods

IgM and IgG antibody levels were assessed via chemiluminescence immunoassay in 338 COVID-19 patients.

Results

IgM levels increased during the first week after SARS-CoV-2 infection, peaked 2 weeks and then reduced to near-background levels in most patients. IgG was detectable after 1 week and was maintained at a high level for a long period. The positive rates of IgM and/or IgG antibody detections were not significantly different among the mild, severe and critical disease groups. Severe and critical cases had higher IgM levels than mild cases, where

SUBMITTER: Hou H 

PROVIDER: S-EPMC7202656 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature