Distinct Patterns of Atypical Functional Connectivity in Lower-Functioning Autism.

ABSTRACT:

Background

Functional magnetic resonance imaging research on autism spectrum disorders (ASDs) has been largely limited to individuals with near-average intelligence. Although cognitive impairment is common in ASDs, functional network connectivity in this population remains poorly understood. Specifically, it remains unknown whether lower-functioning individuals exhibit exacerbated connectivity abnormalities similar to those previously detected in higher-functioning samples or specific divergent patterns of connectivity.

Methods

Resting-state functional magnetic resonance imaging data from 88 children (44 ASD, 44 typically developing; average age: 11 years) were included. Based on IQ, individuals with ASDs were assigned to either a lower-functioning group (mean IQ = 77 ± 6) o

SUBMITTER: Reiter MA 

PROVIDER: S-EPMC7202917 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature