Computing 3D Chromatin Configurations from Contact Probability Maps by Inverse Brownian Dynamics.

ABSTRACT: The three-dimensional (3D) organization of chromatin, on the length scale of a few genes, is crucial in determining the functional state-accessibility and amount of gene expression-of the chromatin. Recent advances in chromosome conformation capture experiments provide partial information on the chromatin organization in a cell population, namely the contact count between any segment pairs, but not on the interaction strength that leads to these contact counts. However, given the contact matrix, determining the complete 3D organization of the whole chromatin polymer is an inverse problem. In this work, a novel inverse Brownian dynamics method based on a coarse-grained bead-spring chain model has been proposed to compute the optimal interaction strengths between different segments of chroma

SUBMITTER: Kumari K 

PROVIDER: S-EPMC7203009 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature