Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders.

ABSTRACT: Studies in animal models of autism spectrum disorders (ASD) suggest atypical early neural activity is a core vulnerability mechanism which alters functional connectivity and predisposes to dysmaturation of neural circuits. However, underlying biological changes associated to ASD in humans remain unclear. Results from functional connectivity studies of individuals diagnosed with ASD are highly heterogeneous, in part because of complex life-long secondary and/or compensatory events. To minimize these confounds and examine primary vulnerability mechanisms, we need to investigate very early brain development. Here, we tested the hypothesis that brain functional connectivity is altered in neonates who are vulnerable to this condition due to a family history of ASD. We acquired high temporal res

SUBMITTER: Ciarrusta J 

PROVIDER: S-EPMC7203016 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature