Rational identification and characterisation of peptide ligands for targeting polysialic acid.

ABSTRACT: The alpha-2,8-linked form of the polysaccharide polysialic acid (PSA) has widespread implications in physiological and pathological processes, ranging from neurological development to disease progression. Though the high electronegativity and excluded volume of PSA often promotes interference of biomolecular interactions, PSA-binding ligands have important implications for both biological processes and biotechnological applications. As such, the design, identification, and characterisation of novel ligands towards PSA is critical for expanding knowledge of PSA interactions and achieving selective glycan targeting. Here, we report on a rational approach for the identification of alpha-2,8-PSA-binding peptides, involving design from the endogenous ligand Siglec-11 and multi-platform characte

SUBMITTER: Shastry DG 

PROVIDER: S-EPMC7203153 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature