Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome.

ABSTRACT:

Background and purpose

Restless legs syndrome (RLS) is a neurological disorder which is most commonly identified by an urge to move the legs. It often shows alterations in sensory processing which implies the salience network (SN) is experiencing changes. This study investigates the functional connectivity (FC) between the SN and other areas of the brain in RLS patients during the resting state period.

Methods

Thirty patients with drug naïve idiopathic RLS and 30 healthy age and gender matched controls were included in this study. Resting state fMRIs were performed in the morning during the asymptomatic period. The SN comparisons were conducted between the two groups.

Results

The RLS group showed a reduction in SN FC in the right pyramis, and an increase in SN FC in t

SUBMITTER: Ku J 

PROVIDER: S-EPMC7203171 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature