The Pathophysiology of Degenerative Cervical Myelopathy and the Physiology of Recovery Following Decompression.

ABSTRACT: Background: Degenerative cervical myelopathy (DCM), also known as cervical spondylotic myelopathy is the leading cause of spinal cord compression in adults. The mainstay of treatment is surgical decompression, which leads to partial recovery of symptoms, however, long term prognosis of the condition remains poor. Despite advances in treatment methods, the underlying pathobiology is not well-known. A better understanding of the disease is therefore required for the development of treatments to improve outcomes following surgery. Objective: To systematically evaluate the pathophysiology of DCM and the mechanism underlying recovery following decompression. Methods: A total of 13,808 published articles were identified in our systematic search of electronic databases (PUBMED, WEB OF SCIENCE). A

SUBMITTER: Akter F 

PROVIDER: S-EPMC7203415 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature