Contribution of 'clinically negligible' residual kidney function to clearance of uremic solutes.

ABSTRACT: BACKGROUND:Residual kidney function (RKF) is thought to exert beneficial effects through clearance of uremic toxins. However, the level of native kidney function where clearance becomes negligible is not known. METHODS:We aimed to assess whether levels of nonurea solutes differed among patients with 'clinically negligible' RKF compared with those with no RKF. The hemodialysis study excluded patients with urinary urea clearance >1.5 mL/min, below which RKF was considered to be 'clinically negligible'. We measured eight nonurea solutes from 1280 patients participating in this study and calculated the relative difference in solute levels among patients with and without RKF based on measured urinary urea clearance. RESULTS:The mean age of the participants was 57 years and 57% were female. At b

SUBMITTER: Toth-Manikowski SM 

PROVIDER: S-EPMC7203561 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature