Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection.

ABSTRACT:

Importance

Spontaneous coronary artery dissection (SCAD), an idiopathic disorder that predominantly affects young to middle-aged women, has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden cardiac death.

Objective

To identify common single-nucleotide variants (SNVs) associated with SCAD susceptibility.

Design, setting, and participants

This single-center genome-wide association study examined approximately 5 million genotyped and imputed SNVs and subsequent SNV-targeted replication analysis results in individuals enrolled in the Mayo Clinic SCAD registry from August 30, 2011, to August 2, 2018. Data analysis was performed from June 21, 2017, to December 30, 2019.

Main outcomes and measures

Genetic loci and positional c

SUBMITTER: Turley TN 

PROVIDER: S-EPMC7203673 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature