The Transcription Factor Stp2 Is Important for Candida albicans Biofilm Establishment and Sustainability.

ABSTRACT: The fungal pathogen Candida albicans forms polymorphic biofilms where hyphal morphogenesis and metabolic adaptation are tightly coordinated by a complex intertwined network of transcription factors. The sensing and metabolism of amino acids play important roles during various phases of biofilm development - from adhesion to maturation. Stp2 is a transcription factor that activates the expression of amino acid permease genes and is required for environmental alkalinization and hyphal growth in vitro and during macrophage phagocytosis. While it is well established that Stp2 is activated in response to external amino acids, its role in biofilm formation remains unknown. In addition to widely used techniques, we applied newly developed approaches for automated image analysis to quantify Stp2-r

SUBMITTER: Bottcher B 

PROVIDER: S-EPMC7203782 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature