Identification of functional mutations associated with environmental variance of litter size in rabbits.

ABSTRACT:

Background

Environmental variance (V_E) is partly under genetic control and has recently been proposed as a measure of resilience. Unravelling the genetic background of the V_E of complex traits could help to improve resilience of livestock and stabilize their production across farming systems. The objective of this study was to identify genes and functional mutations associated with variation in V_E of litter size (LS) in rabbits. To achieve this, we combined the results of a genome-wide association study (GWAS) and a whole-genome sequencing (WGS) analysis using data from two divergently selected rabbit lines for high and low V_E of LS. These lines differ in terms of biomarkers of immune response and mortality. Moreover, rabbits with a lower

SUBMITTER: Casto-Rebollo C 

PROVIDER: S-EPMC7203823 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature