The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study.

ABSTRACT:

Background

The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels of inflammation and the loads of aggregated β-amyloid and tau at baseline and again after 2 years in prodromal Alzheimer's disease.

Methods

Forty-three subjects with mild cognitive impairment (MCI) had serial ¹¹C-PK11195 PET over 2 years to measure inflammation changes, and ¹¹C-PiB PET to determine β-amyloid fibril load; 22 also had serial ¹⁸F-Flortaucipir PET to determine tau tangle load. Cortical surface statistical mapping was used to localise areas showing significant changes in tracer binding over time and to interrogate correlations between tracer binding of the tracers at baseline and after 2 years.

Res

SUBMITTER: Ismail R 

PROVIDER: S-EPMC7203856 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature