Circulating microRNAs correlate to clinical parameters in individuals with allergic and non-allergic asthma.

ABSTRACT:

Background

Asthma is a chronic airway disease affecting millions of people. Better methods to define asthma subgroups using clinical parameters and molecular biomarkers are crucial in the development of personalized medicine.

Objective

The aim of this study was to determine if circulating microRNAs (miRNAs) may be used to distinguish well-defined asthma groups.

Methods

Blood serum from 116 well-defined subjects, including healthy controls and individuals with allergic or non-allergic asthma, from the West Sweden Asthma Study were included. Serum was analyzed for circulating miRNA expression of miR-126, - 145, -146a, - 155, - 223, and -374a and eosinophil cationic protein (ECP). Correlations between clinical characteristics and circulating miRNA expression as well as p

SUBMITTER: Weidner J 

PROVIDER: S-EPMC7203878 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature