The effect of 50% oxygen on PtCO₂ in patients with stable COPD, bronchiectasis, and neuromuscular disease or kyphoscoliosis: randomised cross-over trials.

ABSTRACT:

Background

High-concentration oxygen therapy causes increased arterial partial pressure of carbon dioxide (PaCO₂) in patients with COPD, asthma, pneumonia, obesity and acute lung injury. The objective of these studies was to investigate whether this physiological response to oxygen therapy occurs in stable patients with neuromuscular disease or kyphoscoliosis, and bronchiectasis.

Methods

Three randomised cross-over trials recruited stable patients with neuromuscular disease or kyphoscoliosis (n = 20), bronchiectasis (n = 24), and COPD (n = 24). Participants were randomised to receive 50% oxygen and 21% oxygen (air), each for 30 min, in randomly assigned order. The primary outcome was transcutaneous partial pressure of carbon dioxide (PtCO₂) at 30 min. T

SUBMITTER: Pilcher J 

PROVIDER: S-EPMC7203892 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature