Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex.

ABSTRACT:

Background

Survivin and XIAP are two important members of the inhibitor of apoptosis protein family and have been considered as potential targets for cancer treatment due to their overexpression in large variety of cancers including colorectal cancer. It has been reported that survivin and XIAP can synergistically inhibit apoptosis by forming survivin-XIAP complex. In this study, we aimed to design a peptide that targets the survivin-XIAP complex and elucidate its anticancer mechanisms in colorectal cancer cells.

Methods

We designed and synthetized Sur-X, the peptide targeting survivin-XIAP complex. The anticancer effects of Sur-X were evaluated both in vitro and in vivo. The underlying molecular mechanisms were also investigated.

Results

Sur-X exhibited potent inhibi

SUBMITTER: Fang W 

PROVIDER: S-EPMC7203900 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature