The association between serum chloride levels and chronic kidney disease progression: a cohort study.

ABSTRACT:

Background

Limited data suggest serum chloride levels associate with mortality in heart failure, chronic kidney disease (CKD), and pulmonary arterial hypertension. Randomized trials have also shown that administration of crystalloid intravenous fluids with lower chloride concentration may have better renal outcomes. However, chloride has not been studied longitudinally for CKD progression.

Methods

We used a prospective cohort of subjects with stage 3 and 4 CKD recruited from a nephrology clinic at a single medical center. Linear regression, linear regression with generalized estimating equations, and Cox proportional hazards models were created for outcomes of overall change in estimated glomerular filtration rate (eGFR), longitudinal changes in eGFR, and time to > 30% decli

SUBMITTER: Khatri M 

PROVIDER: S-EPMC7203999 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature