Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers.

ABSTRACT:

Background

Cell-bound membrane vesicles (CBMVs) are a type of membrane vesicles different from the well-known extracellular vesicles (EVs). In recent years, the applications of EVs as drug delivery systems have been studied widely. A question may arise whether isolated CBMVs also have the possibility of being recruited as a drug delivery system or nanocarrier?

Methods

To test the possibility, CBMVs were isolated/purified from the surfaces of cultured endothelial cells, loaded with a putative antitumor drug doxorubicin (Dox), and characterized. Subsequently, cellular experiments and animal experiments using mouse models were performed to determine the in vitro and in vivo antitumor effects of Dox-loaded CBMVs (Dox-CBMVs or Dox@CBMVs), respectively.

Results

Both Dox-fre

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7204042 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature