Development and validation of a five-immune gene prognostic risk model in colon cancer.

ABSTRACT:

Background

Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. Currently, immunotherapy is a rapidly developing therapeutic modality of colon cancer. This study aimed to construct a prognostic risk model based on immune genes for the early diagnosis and accurate prognostic prediction of colon cancer.

Methods

Transcriptomic data and clinical data were downloaded from The Cancer Genome Atlas database. Immune genes were obtained from the ImmPort database. Differentially expressed (DE) immune genes between 473 colon cancer and 41 adjacent normal tissues were identified. The entire cohort was randomly divided into the training and testing cohort. The training cohort was used to construct the prognostic model. The t

SUBMITTER: Chen H 

PROVIDER: S-EPMC7204296 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature