A Network Pharmacology-Based Study on the Anti-Lung Cancer Effect of Dipsaci Radix.

ABSTRACT:

Objective

Dipsaci Radix (DR) has been used to treat fracture and osteoporosis. Recent reports have shown that myeloid cells from bone marrow can promote the proliferation of lung cancer. However, the action and mechanism of DR has not been well defined in lung cancer. The aim of the present study was to define molecular mechanisms of DR as a potential therapeutic approach to treat lung cancer.

Methods

Active compounds of DR with oral bioavailability ≥30% and drug-likeness index ≥0.18 were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform. The potential target genes of the active compounds and bone were identified by PharmMapper and GeneCards, respectively. The compound-target network and protein-protein interaction network wer

SUBMITTER: Wu J 

PROVIDER: S-EPMC7204368 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature